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. 2020 Oct 8;98(6):1502–1518. doi: 10.1016/j.kint.2020.09.015

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© 2020 International Society of Nephrology. Published by Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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In situ detection of angiotensin-converting enzyme 2 (ACE2) in deidentified living donor (LD) and diabetic kidney disease tissue.In situ hybridization for ACE2 mRNA in (a,b) 2 LD reference control biopsies, (c,d) 2 renal biopsies from patients with mild diabetic nephropathy, and (e,f) 2 cases of advanced diabetic nephropathy. Small brown dots representing ACE2 mRNA transcripts are seen scattered at low density in proximal tubules (PTs) of control biopsies (a,b) and at higher density in mild (c,d) and advanced (e,f) diabetic nephropathy. Small brown dots can also be seen in parietal cells in control biopsies (a) and mild diabetic nephropathy (c). No ACE2 transcript signal is seen in distal tubules (D), glomeruli (G), or arterioles (A). Original magnification ×200. Bars = 50 μm. Arrowheads indicate parietal cells. To optimize viewing of this image, please see the online version of this article at www.kidney-international.org/.