Figure 4.

Functional summary of diabetic kidney disease (DKD) angiotensin-converting enzyme 2–positive (ACE2+) expression signature. (a) ACE2+ coexpression signatures were used for community clustering in a positive proximal tubular epithelial cell–specific functional network to identify enriched processes and pathways in DKD biopsy samples. (b) Highlight of ACE2+ signature genes (red circles) shared with the set of proteins that increase expression in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (Bojkova proteome³⁶; Supplementary Table S6). Red text indicates modules with the strongest overlap (P < 0.05), highlighting modules and processes in the ACE2+ signature relevant to SARS-CoV-2 infection.