Fig. 1.

Two-year follow-up of relevant clinical parameters in the six patients Absolute neutrophil (a) and eosinophil counts (with values within the first 3 months highlighted in the panel to the right) (b) followed over the 2-year period since TGN1412-induced cytokine storm show that three of the patients had mild intermittent neutropenia and three had intermittent eosinophilia. The latter three patients also had elevated levels of IgE (c), not always correlating with the elevated eosinophil counts. Horizontal dashed lines indicate the normal control reference ranges for each parameter. Normal reference ranges were determined for a healthy population in the clinical pathology accredited hematology laboratory using standard operating procedures