Table 2. Summary of the results of univariate and multivariate analyses of the risk factors for the OS of patients with melanoma in the TCGA-SKCM cohort, the TCGA-UVM cohort, and the GEO cohort.
| Datasets | Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95% CI) | P‑value | HR (95% CI) | P‑value | ||
| TCGA-SKCM (Training dataset) | Age | 1.023(1.007−1.039) | 0.005 | 1.012(0.997−1.028) | 0.129 |
| Gender | 1.297(0.770−2.185) | 0.328 | 1.115(0.645−1.926) | 0.697 | |
| Stage | 1.538(1.205−1.962) | <0.001 | 1.210(0.557−2.625) | 0.630 | |
| T stage | 1.828(1.431−2.337) | <0.001 | 1.428(0.885−2.305) | 0.145 | |
| N stage | 1.546(1.212−1.973) | <0.001 | 0.970(0.526−1.791) | 0.923 | |
| Clark level | 1.506(1.128−2.011) | 0.006 | 0.819(0.565−1.188) | 0.293 | |
| Risk-score | 3.831(2.726−5.383) | <0.001 | 3.453(2.392−4.985) | <0.001 | |
| GSE65904 (Validation dataset) | Age | 0.997(0.982−1.012) | 0.713 | 1.000(0.985−1.015) | 0.986 |
| Gender | 1.302(0.832−2.039) | 0.249 | 1.316(0.838−2.065) | 0.233 | |
| Stage | 1.405(1.167−1.692) | <0.001 | 1.457(1.211−1.754) | <0.001 | |
| Risk-score | 1.723(1.226−2.423) | 0.002 | 1.902(1.319−2.744) | <0.001 | |
| TCGA-UVM (Validation dataset) | Age | 1.046(1.008–1.085) | 0.019 | 1.051(1.012–1.092) | 0.010 |
| Gender | 1.542(0.651–3.652) | 0.325 | 1.376(0.563–3.366) | 0.484 | |
| Stage | 1.311(0.839–2.048) | 0.234 | 1.392(0.862–2.246) | 0.176 | |
| T stage | 1.941(0.712–5.294) | 0.195 | 1.506(0.529–4.291) | 0.443 | |
| Risk-score | 5.213(1.686–16.120) | 0.004 | 7.645(2.054–28.452) | 0.002 | |
Abbreviations: HR, hazard ratio; CI, confidence interval