Fig 5. Modulating the excitability gradient changes domino speed.

Example traces of seizure-like events induced with application of 4-AP in panels a1 and b1, and with subsequent application of diazepam a2 or Ro19-4603 b2 [13]. Scale bar: 500 μV, 5s. Panel c shows the mean recruitment time of model simulations of the network with different values of excitability gradient δν. Here we fix the coupling weight A = 0.1 and ν⁰ = 0.14 in line with the red star values in Fig 4. Increasing the gradient δν gives a slower-domino effect, so slow that the realization is terminated before all nodes escape, whereas decreasing the gradient gives as faster-domino effect.