Table 3. Clinical characteristics according to the genotype of ORMDL3 (rs7216389).
| AERD (n = 43) | ATA (n = 42) | |||||
|---|---|---|---|---|---|---|
| TT (n = 24) | CT+CC (n = 19) | P value | TT (n = 22) | CT+CC (n = 20) | P value | |
| Age (year) | 42.46± 43.74 | 43.74 ± 12.58 | 0.772 | 47.05 ± 11.68 | 44.15 ± 14.23 | 0.474 |
| Gender (Female) | 15 (62.5%) | 15 (78.9%) | 0.244 | 17 (77.3%) | 17 (85.0%) | 0.524 |
| Atopy | 10 (41.7%) | 12 (63.2%) | 0.161 | 9 (40.9%) | 9 (47.4%) | 0.678 |
| Total IgE (KU/L) | 411.08 ± 502.43 | 700.94 ± 11887.10 | 0.330 | 500.14 ± 1063.42 | 425.63 ± 668.96 | 0.794 |
| Peripheral eosinophil count (/μL) | 605.28 ± 488.90 | 454.03 ± 367.75 | 0.269 | 484.55 ± 471.90 | 793.20 ± 620.70 | 0.079 |
| FeNO (ppb) | 47.75 ± 26.94 | 84.2 ± 62.01 | 0.269 | 43.20 ± 20.43 | 51.67 ± 46.05 | 0.707 |
| Baseline FEV1(% Pred) | 76.73 ± 18.24 | 86.51 ± 14.07 | 0.061 | 78.81 ± 16.43 | 80.18 ± 18.89 | 0.806 |
| Baseline FVC (%) | 79.51 ± 7.51 | 90.25 ± 9.06 | 0.026 | 81.45 ± 19.00 | 82.29 ± 14.29 | 0.921 |
| Baseline MMEF (%) | 35.79 ± 7.68 | 55.93 ± 21.35 | 0.069 | 62.45 ± 27.06 | 46.58 ± 18.97 | 0.188 |
| Baseline FEV1/FVC (%) | 73.27 ± 10.16 | 78.27 ± 8.78 | 0.130 | 81.68 ± 7.92 | 76.51 ± 9.44 | 0.218 |
| PC 20 of methacholine (mg/mL) | 1.19 ± 1.46 | 6.03 ± 7.83 | 0.030 | 3.96 ± 2.81 | 3.73 ± 5.22 | 0.145 |
AERD, aspirin exacerbated respiratory disease; ATA, aspirin tolerant asthma.