Table 1. Deleterious protein-coding variants in strong LD with LD-independent genome-wide significant SNPs associated with hearing difficulty.

Risk Locus	SNP	rsID	MAF	GWAS P-Value	Beta	r2	Ind. Sig. SNP	Gene Symbol	A.A. Change	CADD
6	4:17524570 C/G	rs13147559	0.13	8.4e-9	0.02	0.97	rs13148153	CLRN2	Leu113Val	23.6
8	6:43273604 A/G	rs2242416	0.42	1.3e-18	0.02	1.00	rs10948071	CRIP3	Ile188Thr	23.8
9	6:133789728 A/G	rs9493627	0.31	7.7e-10	0.01	1.00	rs9493627	EYA4	Gly223Ser	26
13	8:82670771 A/G	rs35094336	0.08	2.5e-08	0.02	0.97	rs74544416	CHMP4C	Ala232Thr	26.4
21	11:89017961 A/G	rs1126809	0.25	4.9e-15	0.02	1.00	rs1126809	TYR	Arg402Gln	34
30	22:38121152 A/C	rs9610841	0.39	1.7e-10	0.01	1.00	rs739137	TRIOBP	Asn863Lys	22.8
30	22:38122122 C/T	rs5756795	0.39	NA	NA	1.00	rs739137	TRIOBP	Phe1187Leu	14.29
30	22:38485540 A/G	rs17856487	0.41	NA	NA	0.98	rs132929	BAIAP2L2	Cys252Arg	11.23
31	22:50988105 A/G	rs36062310	0.04	7.9e-16	0.04	1.00	rs36062310	KLHDC7B	Val504Met	16.21