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. 2020 Sep 28;18(9):e3000870. doi: 10.1371/journal.pbio.3000870

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© 2020 Beyene et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — Linear regression analysis between sex and log-transformed concentrations of each lipid species was performed adjusting for age, BMI, total cholesterol, HDL-C, and triglycerides (n = 10,339). The beta coefficients were converted to percentage difference for men relative to women. (A) Associations between sex and lipid classes/subclasses. (B) Associations between sex and sphingolipid species. (C) Associations between sex and phospholipid species. (D) Associations between sex and glycerolipid and fatty-acyl species. Grey circles show nonsignificant classes/subclasses and species, blue circles show classes/subclasses and species with corrected p < 0.05, and pink circles represent the most significantly associated classes/subclasses and species. Whiskers represent 95% confidence intervals. The underlying data can be found in S1 Data. BMI, body mass index; CE, cholesteryl ester; Cer, ceramide; Cer-1-P, ceramide-1-phosphate; COH, free cholesterol; DE, dehydrocholesterol; deoxyCer, deoxyceramide; DG, diacylglycerol; dhCer, dihydroceramide; GM1, G_M1 ganglioside; GM3, G_M3 ganglioside; HDL-C, high-density lipoprotein cholesterol; HexCer, monohexosylceramide; Hex2Cer, dihexosylceramide; Hex3Cer, trihexosylceramide; LPC, lysophosphatidylcholine; LPC(O), lysoalkylphosphatidylcholine; LPC(P), lysoalkenylphosphatidylcholine; LPE, lysophosphatidylethanolamine; LPE(P), lysoalkenylphosphatidylethanolamine; LPI, lysophosphatidylinositol; NL, neutral loss; PC, phosphatidylcholine; PC(O), alkylphosphatidylcholine; PC(P), alkenylphosphatidylcholine; PE, phosphatidylethanolamine; PE(O), alkylphosphatidylethanolamine; PE(P), alkenylphosphatidylethanolamine; PG, phosphatidylglycerol; PI, phosphatidylinositol; SM, sphingomyelin; sn, stereospecifically numbered; Sph, sphingosine; S-1-P, sphingosine-1-phosphate; TG, triacylglycerol; TG(O), alkyl-diacylglycerol.