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. 2020 Sep 28;18(9):e3000870. doi: 10.1371/journal.pbio.3000870

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© 2020 Beyene et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — Linear regression of age against lipid classes/subclasses (A) and lipid species (B) adjusting for sex, BMI, total cholesterol, HDL-C, and triglycerides and including an age × sex interaction term. Pink and blue solid circles show classes and species that are significantly associated with age in women and men respectively (corrected p < 0.05). Open circles represent nonsignificant classes/subclasses or species (corrected p > 0.05). All lipid classes/subclasses showing significant sex interaction (interaction p < 0.05) and the 10 most significantly different species between men and women (interaction p-value < 1.0 × 10⁻²²) in the association with age are labelled. Whiskers represent 95% confidence intervals. See S1 Data for the underlying data. BMI, body mass index; CE, cholesteryl ester; Cer, ceramide; Cer-1-P, ceramide-1-phosphate; COH, free cholesterol; DE, dehydrocholesterol; deoxyCer, deoxyceramide; DG, diacylglycerol; dhCer, dihydroceramide; GM1, G_M1 ganglioside; GM3, G_M3 ganglioside; HDL-C, high-density lipoprotein cholesterol; HexCer, monohexosylceramide; Hex2Cer, dihexosylceramide; Hex3Cer, trihexosylceramide; LPC, lysophosphatidylcholine; LPC(O), lysoalkylphosphatidylcholine; LPC(P), lysoalkenylphosphatidylcholine; LPE, lysophosphatidylethanolamine; LPE(P), lysoalkenylphosphatidylethanolamine; LPI, lysophosphatidylinositol; NL, neutral loss; PC, phosphatidylcholine; PC(O), alkylphosphatidylcholine; PC(P), alkenylphosphatidylcholine; PE, phosphatidylethanolamine; PE(O), alkylphosphatidylethanolamine; PE(P), alkenylphosphatidylethanolamine; PG, phosphatidylglycerol; PI, phosphatidylinositol; PS, phosphatidylserine; SM, sphingomyelin; sn, stereospecifically numbered; Sph, sphingosine; S-1-P, sphingosine-1-phosphate; TG, triacylglycerol; TG(O), alkyl-diacylglycerol.