Table 1.
MiR dysregulated in localized PCa.
| Local PCa OncomiR | PCa phenotype and target assays | Pathway/mRNA target | Patient samples | References |
|---|---|---|---|---|
| miR-30d | SQX, L | Angiogenesis/MYPT1 | N = 12, matched frozen RP; N = 225 PCa and N = 25 benign FFPE RP; MSKCC and TCGA | [19] |
| miR-182 | SQX | Wnt pathway | N = 25, paired fresh RP | [17] |
| miR-183 cluster | SQX | Metabolism/ZIP1 | N = 2 PrE cells | [24] |
| miR-193a-5p | SQX, L | EMT/PCHDA | N = 62, FFPE RP; N = 35, benign, FFPE TURP | [8] |
| miR-486-5p | SQX, L | TGFβ/SMAD2 | N = 23, paired FFPE RP; GSE36802, GSE8126, GSE23022, MSKCC, GSE54010, GSE45604 | [12] |
| miR-543 | OX, L | EMT/RKIP | N = 42, fresh and FFPE RP | [5] |
| miR-590-3p | SQX, L | INPP4B | N = 28, paired biopsy | [27] |
| Local PCa TS miR | PCa phenotype and target assays | Pathway/mRNA target | Patient samples | References |
| miR-124-3p, miR-129-5p, miR-378 | L | Metabolism/CPT1A, CACT, CRAT | N = 30, FFPE RP LCM | [25] |
| miR-33a | L | Metabolism/PIM1 | N = 18, paired frozen RP; MSKCC | [26] |
| miR-129 | SQX, L | EMT/Growth/EST1 | N = 30, paired frozen RP | [7] |
| miR-143 | SQX with nanoparticle miR delivery, L | UPAR | N = 26, frozen RP | [33] |
| miR-150 | SQX, L | EMT/WNT/TRPM4 | N = 87, paired frozen RP; GSE30994, GSE38241, GSE46602, GSE55945, GSE103512, TCGA | [18] |
| miR-200c-3p | SQX, L | EMT/ZEB2 | N = 22, paired RP; TCGA | [6] |
| miR-218 | SQX, rabbit corneal assay, L | Angiogenesis/RICTOR | GSE21036 | [20] |
| miR-199a-5p | L | Angiogenesis/HIF-1A | N = 134, PCa; N = 69 benign FFPE needle biopsy and transurethral resection; N = 6 frozen RP | [21] |
| miR-338-3p | SQX, L | Growth/RAB23 | N = 24, paired frozen RP; GSE21036 | [35] |
| miR-384 | SQX, L | HOXB7 | [34] | |
| miR-487a-3p | SQX, L | Growth/CCND1 | GSE8126, GSE6956; PCa tissue chip | [29] |
| miR-212 | SQX, L | Proliferation/EN2 | N = 58, paired frozen RP | [31] |
| miR-455-3p | SQX, L | Proliferation/eIF4E | N = 47, PCa; N = 18 benign; N = 10 paired frozen RP | [30] |
| miR-491-5p | SQX, L | PDGFRA | N = 18, paired frozen RP | [28] |
| miR-10a | SQX, L | YAP pathway/KDM4A | N = 34, paired RP | [32] |
| miR-539 | SQX, L | EMT/TGFβ/DLX1 | N = 134, RP; GSE55945, GSE45016, GSE38241, TCGA | [11] |
| miR-198 | SQX | MIB1 | CPC-GENE | [36] |
PDX = patient-derived xenograft; OX = orthotopic xenograft; SQX = subcutaneous xenograft; L = luciferase; ICI = intracardiac injection; CAM = chick chorioallantoic membrane assay; TVI = tail vein injection; ZEM = zebrafish extravasation assay; RP = radical prostatectomy; BPH = benign prostatic hyperplasia; PCa = prostate cancer; PrE = primary epithelial cell; TURP = transurethral resection of the prostate; TCGA = The Cancer Genome Atlas; CPC-GENE = The Canadian Prostate Cancer Genome Network; MSKCC = Memorial Sloan Kettering Cancer Center data set (GSE21032); GSE# = NCBI GEO accession ID.