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. 2020 Sep 18;48(18):10199–10210. doi: 10.1093/nar/gkaa724

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — HCHC catalytic activity is necessary for Δlsd1-induced hyper DNA methylation. (A) WGBS tracks displaying DNA methylation in wild-type (WT), Δhda-1, and Δlsd1 strains at selected Δlsd1-sensitive regions. (B) DNA methylation-sensitive Southern hybridizations probing the regions illustrated in panel A showing the loss of Δlsd1-induced hypermethylation in a hda-1 catalytic-null background in sibling strains. The Southern probes used are indicated by a red bar in panel A. Strains (left to right): N3753, N4711, N3998, N6412, N8089 and N8090. (C) ChIP-seq tracks showing H3K9me3 enrichment in WT, Δlsd1 and Δlsd1; hda-1^D263N strains at selected Δlsd1-sensitive regions.