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. 2020 Sep 17;48(18):10087–10100. doi: 10.1093/nar/gkaa737

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — The m⁴C and m⁴₂C pairing with G. (A) The m⁴C5:G6 pair (from chain C and B, respectively) of the CCGG(m⁴C)GCCGG duplex and (B) m⁴₂C5:G6 pair (from chain B and A, respectively) of the CCGG(m⁴₂C)GCCGG structure in P2₁2₁2₁ space group; dashed lines indicate hydrogen bonds; blue mesh represents 2F_o – F_c electron density map (contoured at 1σ) for m⁴C and m⁴₂C; green mesh is the omit F_o – F_c map (contoured at 3σ) calculated only for methyl groups of the modified nucleotides. (C) Two possible forms of the m⁴₂C5:G6 pair.