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. 2020 Sep 29;48(18):10164–10183. doi: 10.1093/nar/gkaa788

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Potential upstream regulators of miR-155 in context with T cell activation. (A) Top 10 list of potential regulators of MIR155HG gene sorted by their mean distance correlation on all investigated data sets. (B) Network of miR-155 and its potential upstream regulators IRF4, SPI1, BATF and annotation of corresponding binding motifs of their complexes within the regulatory regions of MIR155HG gene. (C) Time-resolved expression patterns (Median results of the mRNA data) of IRF4 and pre-miR-155 (MIR155HG) within 24 h of CD4+ T cell activation. (D) Scatter plot between the expression (TPM: transcripts per million) of IRF4 and MIR155HG in the GTEx data set.