Table 1.
Overview on the functions of miR-155-5p target genes that were identified by dual luciferase reporter assays
| Putative target gene | Function | Reference |
|---|---|---|
| ADD3 | Membrane skeleton protein; regulator of spectrin-actin network; interaction with proteinkinases and Ca2+ binding calmodulin | (54) |
| CYP2U1 | Cytochrome P450 family member; suggested modulation of signal transduction in immune cells | (55,56) |
| DDX17 | RNA helicase; broad impact on RNA metabolism | (57) |
| EZH1 | Component of the Polycomb repressive complex 2; direct negative regulator of transcription | (58) |
| HERC3 | Ubiquitin ligase; regulator of NF-κB signaling | (59) |
| IFT80 | Flagellar transport protein | (51,52) |
| JMY | Transcriptional co-activator in context with p53 | (60) |
| KDM5B | Histone demethylase; negative regulator of transcription | (61) |
| LAT2 | Transmembrane adaptor; fine regulator of lymphocyte activation | (62) |
| LDLRAP1 | Low density lipoprotein receptor adaptor protein; regulator of endocytosis and subcellular localization | (63) |
| S100B | Calcium binding protein of the S100 family; calcium induced signal transduction | (64) |
| SH3BP4 | SH3 domain binding protein; regulator of clathrin endocytosis | (65) |
| SORL1 | Sortilin related receptor; regulator of protein subcellular localisation | (66) |
| STARD8 | Rho GTPase activating protein; negative regulator of Rho-ROCK signaling | (67,68) |
| TADA2B | Transcriptional adaptor protein; transcriptional coactivator | (69) |
| TAF7 | TATA-box binding protein associated factor; regulator of transcriptional initiation | (70) |
| ZFP36 | RNA-binding protein; inductor of targeted mRNA degradation | (71) |