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. 2020 Sep 1;48(18):10542–10554. doi: 10.1093/nar/gkaa710

Figure 4.

Figure 4.

rA2RE11 and rA2RE21 prevent phase separation and aggregation of full-length hnRNPA2 WT and mutants. See also Supplementary Figure S4. (A) After cleavage of a C-terminal maltose binding protein solubility tag by TEV protease, hnRNPA2 FL WT undergoes LLPS. In the presence of either rA2RE11 or rA2RE21, hnRNPA2 FL WT does not undergo LLPS. (B, C) After cleavage of a C-terminal maltose binding protein solubility tag by TEV protease, hnRNPA2 FL D290V (B) and P298L (C) undergo LLPS followed by aggregation. In the presence of either rA2RE11 or rA2RE21, neither phase separation nor aggregation occur.