Table 2.

RDC analysis

		Euler angles (°)a
	Number of RDCs	ϕ	θ	ψ	Da (Hz)a	η a	R-factor (%)b
RRM1	40	93	78	95	10.6	0.23	18.8
RRM2	31	189	68	94	9.2	0.55	18.9
hnRNPA2 1–189	71	97	82	108	9.1	0.47	29.4

^aThe alignment tensor is described by five parameters: three Euler angles (ϕ, θ and ψ), the magnitude of the alignment tensor D_a, and the rhombicity η. The fact that the values of the alignment tensors of the N- and C-terminal domains are substantially different indicates that their relative orientation is solution differs from the one observed in the crystal structure of apo hnRNPA2.

^bThe RDC R-factor is given by 100 × [〈(D_obs – D_calc)²〉/(2〈D_obs〉²]^1?2, where D_obs and D_calc are the observed and calculated RDCs, respectively (24).