Figure 2.

Example of workflow on the HERC5 primate gene. The workflow follows the diagram from Figure 1. Using human HERC5 CDS as the starting point in DGINN gave results for both HERC5 and HERC6. The number of sequences (seq) retrieved or left after each step is indicated. In the bottom panel, each colored circle represents the results from one of the five methods to detect positive selection at the gene level, with red representing significant evidence of positive selection and blue no significant evidence. P-values are indicated below the colored circles. Gp, orthologous group.