Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 29;48(18):10101–10124. doi: 10.1093/nar/gkaa750

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Scheme 2. — Reagents and conditions: (i) 80% aq. TFA/DCM, 0°C to room temperature, overnight; 83% for 5, 70% for 15. (ii) Benzoic anhydride, DMAP/pyridine, room temperature, overnight; 99% for 6 and for 16. (iii) TBAF/THF, room temperature, overnight; 87% for 7, 94% for 17. (iv) DMTrCl, AgNO₃/THF/pyridine (THF/pyridine, 4:1, v/v), room temperature, overnight; 98% for 8, 98% for 18. (v) NaOH/THF/MeOH (THF/MeOH, 1:1, v/v), 0°C, 30 min; 96% for 9 and for 19. (vi) TBSCl, AgNO₃/THF/pyridine (THF/pyridine, 4:1, v/v), room temperature, overnight; 50% for 10, 53% for 20. (vii) i-Pr₂NP(Cl)O(CH₂)₂CN, DIPEA, 1-methylimidazole/DCM, room temperature, 2 h; 88% for 11, 65% for 21. (viii) 1) Succinic anhydride, DMAP/DCM, room temperature, overnight. 2) LCAA-CPG (pore size 500 Å, 171 μmol/g), HBTU, DIPEA/DMF, room temperature, overnight. 3) Acetic anhydride/pyridine, room temperature, overnight; 70 μmol/g loading for 12, 97 μmol/g for 22.