Skip to main content
. 2020 Sep 29;48(18):10101–10124. doi: 10.1093/nar/gkaa750

Table 3.

Percent C3′-endo conformers of 5′ triphosphates of (R)- and (S)-5′-C-methyl-guanosine based on 1H-NMR

Compound 5′-O group 5′-C group 3 J H1′-H2′ (Hz) % C3′ endo a
Guanosine Triphosphate H 6.0 ∼40
30 Triphosphate (R)-methyl 7.0 ∼30
34 Triphosphate (S)-methyl 6.1 ∼40

aThe percent of molecules in the C3′-endo conformation was calculated as (100 – (10 × 3JH1′–H2′)) as previously described (52), where 3JH1′–H2′ is the 1H NMR coupling constant of the sugar H1′ and H2′ protons.