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Half-lives of oligonucleotides modified at the 5′ termini with 5′-(R)- or 5′-(S)-C-methyl-guanosines in the presence of PDE-II
| 500 mU/ml PDE-II | 100 mU/ml PDE-II | |
|---|---|---|
| Oligonucleotide | t 1/2 (h) | t 1/2 (h) |
| GPOdT19 | <1 | 0.1 |
| S POdT19 | <1 | 0.2 |
| R POdT19 | <1 | 4.3 |
| GPSdT19 | 41 | ND |
| R PSdT19 | No degradation | ND |
| S PSdT19 | 72 | ND |
