Figure 1.

Phylogenetic classification of H-NS family proteins in Enterobacterales. (A) Chromosomal-encoded H-NS homologs. (B) Chromosomal and plasmid-encoded H-NS homologs. The protein clades are categorized as: H-NS (green), StpA (red), Hfp (blue), HlpC (teal), HlpP (purple), HppP (magenta), HppX (orange), HppH (pink), HppE (grey), HppR (grey) and HppF (gold). The bacterial genera that encode the homologs are indicated at the branch tips, and the number of representative protein sequences are in brackets. Clusters of branches that are too small to resolve in the figure are coloured with grey background to improve connections between branches and names. Rooted phylogenies with each branch and species name are provided in Supplementary Figure S2. Phylogenies are derived from maximum likelihood inferences of evolutionary relationships, and the scale bar indicates the number of substitutions per site. Bootstrap scores are shown for ancestral branches that define the clades and sub-clades described in the text.