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. 2020 Oct 9;99(41):e22607. doi: 10.1097/MD.0000000000022607

Figure 2.

Figure 2

Association between ikaros family zinc finger 1-rs4132601 genotype distribution and cytokines in SLE patients. Cytokines in 143 systemic lupus erythematosus patients with different genotype of ikaros family zinc finger 1-rs4132601 (98 TT, 32 GT and 13 GG). (A) IL-6 (pg/mL): TT genotype 3.81 (2.3, 7.14), TG genotype 4.72(2.60,9.54) and GG genotype 3.21(1.55,13.98), P = .48. (B) IL-17A (pg/mL): TT genotype 2.33 (2.18, 3.96), TG genotype 2.18 (0.55, 3.96) and GG genotype 2.48 (2.18, 3.96), P = .69. (C) IFN-γ (pg/mL): TT genotype 5.16 (5.16, 11.99), TG genotype 6.87 (1.75, 10.28) and GG genotype 5.16 (1.75, 11.14), P = .48. (D) TNF-α (pg/mL): TT genotype 5.44 (2.97, 10.57), TG genotype 5.44 (2.13, 10.18) and GG genotype 4.22 (2.55, 9.18), P = .71. (E) CD40L(ng/mL): TT genotype 3.64 (2.20, 5.24), TG genotype 2.89 (2.06, 4.34) and GG genotype 5.46 (3.17, 7.61), P = .04. (F) Granzyme B (pg/mL): TT genotype 6.85 (3.95, 15.02), TG genotype 8.49 (3.74, 23.13) and GG genotype 6.85 (4.36, 23.11), P = .69. The results represent the median and interquartile of cytokines levels.