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. 2020 Apr 16;41(35):3304–3310. doi: 10.1093/eurheartj/ehaa193

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© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Associations of genetic predisposition to smoking initiation with 14 cardiovascular diseases in UK Biobank. The odds ratios correspond to the increase of one standard deviation in prevalence of smoking initiation (ever smoked regularly). Estimates are from the multiplicative random-effects inverse variance-weighted method. CI, confidence interval; OR, odds ratio. The I ² statistic quantifies the amount of heterogeneity among estimates based on individual SNPs. ^a Significant at the Bonferroni-corrected threshold of P < 3.6 × 10⁻³.