Table 1.
C05-based cyclic peptides have increased breadth of recognition of diverse influenza HA molecules compared to the parental IgG molecule.
| Group | Subtype | Strain | C05 d1 | C05 d4 | C05 IgG |
|---|---|---|---|---|---|
| 1 | H1N1 | A/Solomon Islands/03/2006 | +++ | +++ | ++++ |
| A/Solomon Islands/03/2006 head domain | ++ | ++ | +++ | ||
| A/Brevig Mission/1/1918 | - | - | - | ||
| A/Tottori/YKO 12/2011 | - | - | - | ||
| A/mallard/Alberta/35/1976 | - | - | ++ | ||
| A/Puerto Rico/8/1934 | +++ | +++ | - | ||
| A/Texas/36/1991 | - | - | - | ||
| A/New Caledonia/20/1999 | +++ | +++ | ++ | ||
| A/California/04/2009 | - | ++++ | - | ||
| H2N2 | A/Japan/305/1957 | +++ | ++ | ++++ | |
| A/Singapore/1/1957 | ++++ | +++ | ++++ | ||
| H5N1 | A/Vietnam/1203/2005 | - | - | - | |
| A/lndonesia/5/2005 | - | - | - | ||
| H9N2 | A/turkey/Wisconsin/1/1966 | ++++ | +++ | ++ | |
| H16N3 | A/black-headedgull/Sweden/4/1999 | - | - | - | |
| 2 | H3N2 | A/Hong | +++ | +++ | ++++ |
| Kong/1/68 | - | - | - | ||
| A/Brisbane/10/2007 | +++ | +++ | ++++ | ||
| A/Perth/16/2009 | +++ | - | ++++ | ||
| A/Panama/2007/1999 | - | - | ++++ | ||
| A/Bangkok/1/1979 | - | - | - | ||
| H4N6 | A/duck/Czechoslovakia/1956 | +++ | +++ | ||
| H7N9 | A/Shanghai/02/2013 | +++ | +++ | ||
| A/Netherlands/219/2003 | - | - | - | ||
| H15N8 | A/shearwater/Western Australia/2576/1979 | - | - | - |
++++
<10 nM
+++
10–100 nM
++
100–1,000 nM
-
Specific binding not detected