. Author manuscript; available in PMC: 2021 Oct 6.

Published in final edited form as: Structure. 2020 Jun 30;28(10):1114–1123.e4. doi: 10.1016/j.str.2020.04.005

Table 2.

Buried surface area on the HA of various subtypes.

	Buried surface area on the HA (A²)
Strain	C05 IgG	C05 d1	C05 truncated d4
H1 A/Solomon Islands/03/2006	639	638	586
H1 A/California/04/2009	777	580	569
H1 A/Puerto Rico/8/1934	734	720	593
H2A/Japan/305/1957	753	596	800
H2A/Singapore/1/1957	731	666	634
H3A/Perth/16/2009	780	686	614
H3 A/Hong Kong/1/1968	651	568	609
H4 A/duck/Czechoslovakia/1956	760	597	628
H7A/Shanghai/02/2013	742	588	534
Average	730	627	618

Mock co-complexes of C05 IgG with each subtype were created by aligning the HA structure to antigen in the co-crystal structure of C05 (PDB ID 4fp8). Peptides C05 d1 and C05 truncated d4 were docked into the receptor-binding site of each HA and the buried surface area of the lowest energy model was calculated.