Key Resources Table

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
C05 IgG	Ekiert et al.2012	NA
6x-His Tag Monoclonal Antibody (HIS.H8), HRP	ThermoFisher	MA1–21315-HRP
Bacterial and Virus Strains
Influenza virus strain A/Solomon Island/3/2006	Influenza Reagent Resource of US CDC	FR-331
SHuffle T7 Express competent E. coli	New England BioLabs	C3026J
Biological Samples
Turkey Red Blood Cells	Rockland Inc.	R408–0050
Chemicals, Peptides, and Recombinant Proteins
Rosetta-designed cyclic peptides	This paper	NA
Recombinant HA protein	This paper	NA
HI Vgp120	This paper	NA
TMB substrate	Thermo Fisher	N301
Critical commercial assays
Gibson Assembly Master Mix	New England BioLabs	E2611S
Deposited Data
Crystal structure of apo C05	Ekiert et al. 2012	PDB ID 4fnl
Crystal structure of H1 A/Solomon Islands/03/2006	Schmidt et al. 2013	PDB ID 4hkx
Co-crystal structure of C05 with H3 A/Hong Kong/1/1968	Ekiert et al. 2012	PDB ID 4fp8
Crystal structure of C05 with H3 A/Hong Kong/1/1968	Ekiert et al. 2012	PDB ID 4fnk
Crystal structure of H3 A/Perth/16/2009	Nakamura et al. 2013	PDB ID 4kvn
Crystal structure of H4 A/duck/Czechoslovakia/1956	Song et al. 2017	PDB ID 5xl3
Crystal structure of H7 A/Shanghai/02/2013	Yang et al. 2013	PDB ID 4ln3
Crystal structure of H1 A/California/04/2009	Xu et al. 2011	PDB ID 3ubq
Crystal structure of H1 A/Puerto Rico/8/1934	Gamblin et al. 2004	PDB ID 1rvx
Crystal structure of H2 A/Japan/305/1957	Xu et al. 2010	PDB ID 3ku3
Crystal structure of H2 A/Singapore/1/1957	Liu et al. 2009	PDB ID 2wr7
Experimental Models: Cell Lines
Expi293F cells	Thermo Fisher Scientific	A14527
MDCK cells	ATCC	CCL-34
Recombinant DNA
pcDNA3.1(+)	Invitrogen	V79020
pMAL-c5x	New England BioLabs	N8108S
McLean Ig expression vector	McLean et al. 2000	N/A
Software and Algorithms
Rosetta	Alford et al.2017	https://www.rosettacommons.org/
Amber18	Case et al. 2018	https://ambermd.org
PyMol	Schrodinger, LLC, 2015	http://pymol.org
GraphPad Prism	GraphPad	https://www.graphpad.com/
Code for data analysis	This study	https://github.com/sevya/cyclic_peptide_protocol_capture
PyEMMA Python library version 2.5.7	Scherer et al., 2015	http://emma-proiect.orq/latest/
CPPTraj	Roe and Cheatham, 2013	https://amber-md.aithub.io/coDtrai/CPPTRAJ.xhtml
ForteBio software	N/A	https://www.fortebio.com/products/octet-svstems-software
Other
HisTrap Excel column (5 mL)	GE Healthcare	17371206
HiTrap MabSelectSure column (5 mL)	GE Healthcare	11003494
Pre-coated streptavidin ELISA plate	Thermo Fisher Scientific	15500