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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Neuropharmacology. 2020 Jul 29;178:108220. doi: 10.1016/j.neuropharm.2020.108220

Figure 1.

Figure 1.

Effect of apremilast on the loss of righting reflex (LORR) induced by different sedativehypnotics. Duration of LORR in saline- vs. apremilast (20 mg/kg)-pretreated male and female C57BL/6J mice after i.p. injection of (A) gaboxadol (n = 13–14), (B) zolpidem (n = 7–10), (C) propofol (n = 7–8), (D) etomidate (n = 8–10), or (E) diazepam (n = 9). Data from male and female mice were combined. ****p < 0.0001 compared with the saline-treated group, two-tailed t-test.