Table 2.
Complications in the first birth | Number of women | Number of events / women-years at risk | Age-adjusted models† | Fully adjusted models‡ |
---|---|---|---|---|
Hazard ratio (95% confidence interval) | Hazard ratio (95% confidence interval) | |||
By hypertensive disorder of pregnancy status only | ||||
No HDP | 475,269 | 499 / 5,883,782 | Reference | Reference |
HDP§ | 33,153 | 66 / 399,858 | 1.92 (1.49–2.48)** | 1.83 (1.41–2.36)** |
Gestational hypertension | 8,827 | 15 / 114,919 | 1.38 (0.82–2.30) | 1.41 (0.84–2.35) |
Preeclampsia | 24,326 | 51 / 284,939 | 2.17 (1.63–2.90)** | 2.00 (1.50–2.68)** |
By hypertensive disorder of pregnancy, small-for-gestational age delivery, and preterm delivery status | ||||
No HDP | 475,269 | 499 / 5,883,782 | Reference | Reference |
HDP alone§ | 22,585 | 42 / 273,255 | 1.78 (1.30–2.44)** | 1.72 (1.26–2.36)# |
HDP with preterm and/or SGA delivery§ | 10,568 | 24 / 126,603 | 2.22 (1.48–3.35)** | 2.04 (1.35–3.08)# |
Gestational hypertension alone | 6,948 | 10 / 89,863 | 1.19 (0.63–2.22) | 1.21 (0.65–2.27) |
Gestational hypertension with SGA and/or preterm birth | 1,879 | 5 / 25,056 | 2.02 (0.84–4.88) | 2.06 (0.85–4.98) |
Preeclampsia alone | 15,637 | 32 / 183,393 | 2.11 (1.48–3.02)** | 1.99 (1.39–2.84)** |
Preeclampsia with SGA and/or preterm birth | 8,689 | 19 / 101,547 | 2.28 (1.44–3.61)** | 2.04 (1.28–3.23)# |
Heart failure endpoint is a composite of heart-failure related hospitalization and heart failure-related death
Age-adjusted models are adjusted only for maternal age at the last birth
Fully adjusted models are adjusted for maternal birth year, maternal age at first birth, maternal age at last birth, chronic diabetes diagnosis prior to last birth, and final party
HDP includes both gestational hypertension and preeclampsia
P<0.05,
P<0.01,
P<0.001