Table 3.

Hazard ratios (95% confidence intervals) for heart failure^* by hypertensive disorder of pregnancy status in the first and subsequent births.

HDP status in first birth	HDP status in second and/or subsequent births	Number of women	Events / women-years at risk	Age-adjusted models†	Fully adjusted models‡
				Hazard ratio (95% CI)	Hazard ratio (95% CI)
No HDP	No HDP	382,191	333 / 4,474,400	Reference	Reference
No HDP	No later births	80,147	132 / 1,273,070	1.12 (0.91–1.38)	1.64 (1.26–2.12)**
No HDP	Gestational hypertension but no preeclampsia in later births	4,405	12 / 45,790	3.39 (1.91–6.03)**	3.15 (1.77–5.61)**
No HDP	Preeclampsia in later births	8,526	22 / 90,522	3.33 (2.16–5.14)**	2.92 (1.89–4.50)**
Gestational hypertension	No HDP	5,395	7 / 66,242	1.32 (0.62–2.78)	1.34 (0.64–2.84)
Gestational hypertension	No later births	1,672	5 / 27,200	1.68 (0.69–4.08)	2.58 (1.05–6.34)||
Gestational hypertension	HDP in second and/or later births	1,760	3 / 21,477	1.70 (0.55–5.31)	1.66 (0.53–5.18)
Preeclampsia	No HDP	14,293	17 / 156,015	1.55 (0.95–2.53)	1.46 (0.90–2.39)
Preeclampsia	No later births	4,781	18 / 71,854	2.75 (1.70–4.43)**	3.63 (2.19–6.01)**
Preeclampsia	HDP in second and/or later births	5,252	16 / 57,070	3.83 (2.32–6.32)**	3.47 (2.10–5.75)**

^*Heart failure endpoint is a composite of heart-failure related hospitalization and heart failure-related death

^†Age-adjusted models are adjusted only for maternal age at the last birth

^‡Fully adjusted models are adjusted for maternal birth year, maternal age at first birth, maternal age at last birth, and chronic diabetes diagnosis prior to last birth

^||P<0.05,

^#P<0.01,

^**P<0.001