KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Chemicals, Peptides, and Recombinant Proteins
[13C6]-D-glucose	Cambridge Isotope Laboratories	Cat#CLM-1396–1
2-hydrazinoquinoline	Sigma-Aldrich	Cat#CDS000062
Acetonitrile, Optima LC/MS	Fisher Scientific	Cat# A955
Water, Optima LC/MS	Fisher Scientific	Cat# W6
Methanol, Optima LC/MS	Fisher Scientific	Cat# A456
Ammonium hydroxide, Optima LC/MS	Fisher Scientific	Cat#A470
Formic acid, Optima LC/MS	Fisher Scientific	Cat#A117
Acetic Acid, Glacial	Fisher Scientific	Cat#A38
Ammonium hydroxide, Optima LC/MS	Fisher Scientific	Cat#A470
Deposited Data
13C isotope labeling data (low-infusion)	Hui et al., 2017	https://doi.org/10.1038/nature24057
13C isotope labeling data (high-infusion)	This paper	https://github.com/LocasaleLab/Lactate_MFA/blob/master/data/data_collection_from_Dan.xlsx
Time-series concentration data of circulating metabolites in plasma	This paper	https://github.com/LocasaleLab/Lactate_MFA/blob/master/data/related_data_from_dan.xlsx
Experimental Models: Organisms/Strains
Mouse: C57BL/6J	The Jackson Laboratory	Stock No. 000664
Mouse: Pax7CreER-T2	Laboratory of Chen-Ming Fan, Carnegic Institution for Science	N/A
Mouse: p53fl/fl	Laboratory of Anton Berns, the Netherlands Cancer Institute	N/A
Mouse: LSL-NrasG12D	The Jackson Laboratory	Stock No. 008304
Software and Algorithms
Sieve 2.0	ThermoFisher Scientific	https://portal.thermo-brims.com/index.php/component/thermosoftwares/thermosoftware/67?Itemid=121
NumPy	Open source software	https://numpy.org/
SciPy	Open source software	https://www.scipy.org/
Matplotlib	Open source software	https://matplotlib.org/
xlrd	python-excel	https://github.com/python-excel/xlrd
tqdm	tqdm	https://github.com/tqdm/tqdm
python-ternary	marcharper	https://github.com/marcharper/python-ternary
Docker	Docker Inc.	https://www.docker.com/