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CSF dopamine (panel A) and homovanillic acid (panel B) levels significantly moderate the association between HIV and depressive symptoms. Region of significance analyses estimate that HIV+ individuals have significantly higher depressive symptoms than HIV− individuals only when concentrations of dopamine and homovanillic acid fall within the lower half of their respective distributions (dopamine z ≤ 0.11; homovanillic acid z ≤ 0.06).
