| # | Searches | Results | Type |
|---|---|---|---|
| 1 | exp hydroxymethylglutaryl coenzyme A reductase inhibitor/ | 134783 | Advanced |
| 2 | exp rheumatoid arthritis/ | 160731 | Advanced |
| 3 | 1 and 2 | 1862 | Advanced |
| 4 | clinical study/ or exp case control study/ or exp case study/ or exp clinical trial/ or exp longitudinal study/ or exp major clinical study/ or exp prospective study/ or exp retrospective study/ | 4485701 | Advanced |
| 5 | methodology/ or exp "clinical trial (topic)"/ or exp cohort analysis/ or exp correlational study/ or exp cross-sectional study/ or exp double blind procedure/ or exp evidence based practice/ | 2986990 | Advanced |
| 6 | 3 and (4 or 5) | 911 | Advanced |
| 7 | exp rheumatoid arthritis/ep and 3 | 25 | Advanced |
| 8 | 6 or 7 | 921 |
Footnote:
Description of search strategy: The initial strategy was developed in Ovid MEDLINE (1946-January 22, 2019), using MeSH (Medical Subject Headings) controlled vocabulary and text words for those articles not yet indexed, and then modified the strategy for Ovid EMBASE (1988 through week 03, January 2019). Primary terms were: (Explode Hydroxymethylglutaryl-CoA Reductase Inhibitors/) OR (hmg coa.mp) OR (statin.mp [multiple posting]) OR (hydroxymethylglutaryl coenzyme a reductase inhibitor or atorvastatin or cerivastatin or compactin or fluindostatin or lovastatin or mevinolin or pitavastatin or pravastatin or rosuvastatin or simvastatin OR (explode Dyslipidemias [Drug Therapy, Prevention and Control]) AND (rheumatoid arthritis.mp or explode Arthritis, Rheumatoid/). Explode allows including all of the specific terms without having to use all of the variable terms and synonyms. Multiple posting allows for searching in title, abstract, name of substance word, subject heading word, floating sub-heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier, and synonyms. The same process was used with Ovid EMBASE with changes to accommodate more granular subject headings in EMBASE. Search terms were as follows: (explode hydroxymethylglutaryl coenzyme A reductase inhibitor/) AND (explode rheumatoid arthritis/) AND (clinical study/ or explode case control study/ or explode case study/ or explode clinical trial/ or explode longitudinal study/ or explode major clinical study/ or explode prospective study/ or explode retrospective study/) OR (methodology/ or explode "clinical trial (topic)"/ or explode cohort analysis/ or explode correlational study/ or explode cross-sectional study/ or explode double blind procedure/ or explode evidence based practice/).