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. 2020 Oct 8;10:16802. doi: 10.1038/s41598-020-73912-5

Figure 6.

Figure 6

Schematic illustration of the role of nSMase2 in TNF-α mediated inflammatory response in monocytic cells. The pathway highlights that disruption of nSMase2 activity by GW4869 or SMPD3 suppresses TNF-α induced production of inflammatory markers (CD11c, MCP-1, IL-1β) in monocytic cells. SM, sphingomyelin.