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. 2020 Apr 17;24(11):4019–4030. doi: 10.1007/s00784-020-03272-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Dry mouth relief provided by saliva substitutes. Relief (a) and relief period (b) as explained in Fig. 3 obtained for different natural saliva and saliva substitutes on the tongue-enamel friction system. Relief was obtained based on both the maximum (R_max) and median (R_median) COF. Error bars represent standard deviations over triplicate measurements. Substances tested: demineralized water (DW), unstimulated and stimulated human whole saliva (UWS and SWS respectively), Saliva Orthana (SO), Dentaid Xeros (DX), BioXtra (BX), Biotène (BT), Gum Hydral (GH), Aldiamed (ADM), Saliva Natura (SN), Glandosane (GDS), Aequasyal (AQ). In (a), all tested agents were significantly different (p < 0.05) to UWS in both R_max and R_med except GH gel, depicted by ⁼. ^$ depicts significant differences compared with DW (p < 0.05). * Shows significant difference compared with UWS in Relief Period. Data for DW, SWS, and UWS was taken from [21]