Table 2.
Characteristics of BDNF Val66Met and APOE polymorphisms
| Gene | SNP | CHR | position | Allele 1 | Allele 2 | MAF | MAF gp* | Genotype distribution | HWE | Array** |
|---|---|---|---|---|---|---|---|---|---|---|
| BDNF | Val66Met (rs6265) | 11 | 27,658,369 (CRCh37) | C [Val] | T [Met] | 0.238 | 0.19,437 | ValVal: 247 / ValMet: 161 / MetMet: 22 | 0.51 | Neurochip backbone (Infinium HumanCore-24 v1.0) |
| Allele ε4 distribution | ||||||||||
| APOE | rs429358 | 19 | 45,411,941 (CRCh37) | T | C | 0.214 | 0.138 | ε4-non carriers: 261; ε4 heterozygous: 141; ε4 homozygous: 28 | 0.137 | |
| rs7412 | 19 | 45,412,079 (CRCh37) | C | T | 0.043 | 0.061 | ||||
SNP single nucleotide polymorphisms, BP base position, A1 major allele, A2 minor allele, MAF minor allele frequency, MAF gp* MAF general population. Source: gnomAD genome aggregation database, HWE Hardy weinberg equilibrium
Array source** Blauwendraat et al., NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases. Neurobiology of Aging. 2017 vol: 57 pp: 247.e9-247.e13