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. 2020 Oct 9;183:114278. doi: 10.1016/j.bcp.2020.114278

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Fig. 5 — Targeting carbonic anhydrase to treat glaucoma. Glaucoma is retinal degeneration caused by increased intralocular pressure. Eye drops containing CA-inhibitors such as acetazolamide (ACZ) target CAs in the ciliary body and reduce the production of aqueous humor, lowering intraocular pressure. The ciliary body is a complex epithelial tissue comprised of two cell layers joined by gap junctions. A variety of ABTs and other transporters are required to move NaCl, which is followed by water, from the interstitial fluid into the anterior chamber of the eye. NHE1: Na⁺/H⁺ exchanger 1; AE2: Cl^–/HCO₃^– exchanger 2; CAII: carbonic anhydrase II; CAIV: carbonic anhydrase IV; NBCe1: electrogenic Na⁺/HCO_3⁻ cotransporter.