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. 2020 Oct 9;183:114278. doi: 10.1016/j.bcp.2020.114278

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Fig. 8 — The role of acid-base transporters and carbonic anhydrases (CAs) in bone remodeling. Osteoclasts secrete acid onto the bone surface to resorb minerals during bone growth/remodeling and in response to hormonal requirements for release of mineralized Ca²⁺ and phosphate. One report suggested an off-target bone-sparing effect of CA inhibitors, used to treat glaucoma, in a group of post-menopausal women. NHE1: Na⁺/H⁺ exchanger 1; AE2: Cl^–/HCO₃^– exchanger 2; CAII: carbonic anhydrase II; NBCn1: electroneutral Na⁺/HCO_3⁻ cotransporter.