Table 1.
Virus Hijacking SOCS Proteins Escapes Innate Immunity.
| Virus | Target SOCS | Effect |
|---|---|---|
| PRRSV | ↑SOCS1 | ↓IFN-β, ISGs ↑viral replication |
| HCV | ↑SOCS3 | ↓IFN-α/β ↑viral replication |
| HSV | ↑SOCS3 | ↓IFN-α/β ↑viral replication |
|
IAV RSV WNV ZIKA HCV |
↑SOCS1, 3 ↑SOCS1, 3 ↑SOCS1 ↑SOCS1, SOCS3 ↑SOCS3 |
↓type I and type II IFN, ↑IFN-λ ↑viral replication ↓IFN signal, chemokines, ISGs ↑viral replication ↓type I I IFN ↑viral replication ↓type I and type III interferon ↑viral replication ↓NF-κB, inflammatory response |
↑ increases; ↓ decreases.