Table 2.

MicroRNAs regulate innate immunity through SOCS proteins.

Virus	miRNA	Target SOCS	Effect
IBDV	↑ miR-155	↓ SOCS1	↑ type I IFN ↓ viral replication
IBDV	↑ miR-130b	↓ SOCS5	↑ IFN-β ↓ viral replication
IBDV	↑ miR-454	↓ SOCS6	↓ viral replication
IBDV HCV	↑ miR-27b-3p ↑ miR-221	↓ SOCS3, 6 ↓ SOCS1, SOCS3	↑ IFN-β, IRF3 and NF-κB ↑ anti-HCV IFN, ↑ JAK/STAT signaling
JEV	↓ miR-432	↑ SOCS5	↑ phosphorylation of STAT1, ↑ cellular inflammation, ↑ viral replication
TEGV HSV-2	↓ miR-30a-5p ↑Hsv2-miR-H9-5p	↑ SOCS1, SOCS3 ↓ SOCS2	↓ type I IFN ↑ viral replication

↑ increases; ↓ decreases.