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. 2020 Sep 15:1–13. doi: 10.1080/07391102.2020.1820381

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Figure 7. — (a) Conformational perturbation observed for ^hC5a in response to 0.1–10 µM raloxifene (Ral), suggesting the binding (K_d ∼ 0.71 µM) of raloxifene to ^hC5a (Mishra & Rana, 2019). Few far-UV CD traces have been truncated beyond certain wavelengths to acknowledge the instrumental limitations. (b) The near-UV CD spectra highlighting the effect of 1–10 µM raloxifene (Ral) on the tertiary structure of ^hC5a. (c) Determination of the ANS-^hC5a binding stoichiometry through ANS fluorescence saturation study was performed in the presence of 0.1 µM ^hC5a. (d) The effect of 1–100 µM raloxifene (Ral) on the fluorescence spectra of both ^hC5a and ANS.