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. 2020 Sep 25;11:579894. doi: 10.3389/fimmu.2020.579894

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Copyright © 2020 Narducci, Tosi, Frezzolini, Scala, Passarelli, Bonmassar, Monopoli, Accetturi, Cantonetti, Antonini Cappellini, De Galitiis, Rosato, Picozza, Russo and D’Atri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical presentation and histopathological features of SS. (A) Diffuse erythroderma involving 70% of total body at T0. (B) Reduced erythroderma and presence of vitiligo-like lesion at T8. (C–J) Hematoxylin-eosin (H&E) staining and IHC on lesional skin biopsies. (C) H&E staining of T0 biopsy revealed a dense band of atypical T lymphocytes infiltrating papillary dermis (magnification x10/0.30NA).(D) H&E staining of T18 biopsy revealed a reduced neoplastic infiltrate with a lichenoid aspect (magnification x20/0.40NA). (E–J) IHC analysis for CD3+, CD4+, and CD8+ cells showed a reduction of their density from T0 to T18 (magnification x20/0.40NA).