Table 2.
Perioperative risk factors for POD identified by the logistic regression analysis.
| Variables | Univariable analysis | Multivariable analysis* | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | |
| Duration of surgery, min | 1.00 | 1.00–1.01 | 0.089 | – | – | – |
| APACHE II score | 1.04 | 1.00–1.09 | 0.082 | – | – | – |
| Post-operative blood transfusion, n (%) | 2.03 | 1.19–3.46 | 0.010 | – | – | – |
| BUN, mmol/L | 1.08 | 1.02–1.14 | 0.009 | – | – | – |
| NT-proBNP, log transformed pg/ml | 1.29 | 1.01–1.65 | 0.042 | – | – | – |
| Blood sodium, mmol/L | 1.07 | 1.00–1.14 | 0.056 | – | – | – |
| Blood calcium, mmol/L | 0.01 | 0.00–0.33 | 0.011 | 0.04 | 0.00–1.83 | 0.100 |
| eGFR, per 10 ml/min/1.73 m2 increase | 0.81 | 0.73–0.91 | <0.001 | 0.84 | 0.74–0.95 | 0.005 |
| Midazolam | 3.10 | 1.78–5.42 | <0.001 | 2.35 | 1.31–4.22 | 0.004 |
| Morphine | 2.20 | 1.29–3.77 | 0.004 | 1.83 | 1.04–3.24 | 0.037 |
OR, odds ratio; APACHE, acute physiology and chronic health evaluation; BUN, blood urea nitrogen; NT-proBNP, N-terminal prohormone of brain natriuretic peptide; eGFR, estimated glomerular filtration rate.
*
The model was adjusted by age and gender.