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The antitumor function of some drugs via decreasing the expression of SRSF3. Caffeine, digoxin, amiodarone, amiloride, and theobromine induce the apoptosis of cancer cells by decreasing the expression of SRSF3 and its downstream signaling cascade, including inducing the switch of p53 splicing from p53α to the p53β isoform. Moreover, theophylline and amiodarone could enhance caffeine-induced cell death, and amiodarone could also enhance the efficacy of digoxin.
