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. 2020 Oct 9;27(12):3209–3225. doi: 10.1038/s41418-020-00633-7

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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2020

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 2 — The IFN-I protein is secreted from infected cells and amplifies the IFN response by activating the ISGF3 complex (STAT1/STAT2/IRF9) to induce IFN-I-stimulated genes. The SARS-CoV-2 proteins that inhibit IFN-I signaling are indicated in black boxes, and the associated blocked pathways are indicated by dashed lines.