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. 2020 Sep 25;8:745. doi: 10.3389/fchem.2020.00745

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Copyright © 2020 Fan, Wang, Zhu, Wang, Liu, Wang, Liu, Liu, Fan and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HMSCs treated with magneto mechanical stimulation combined with biochemical factors formed mineralized nodules. Alizarin red and von Kossa co-staining showed positive calcium and phosphorus in the nodules. (a) Undifferentiated hMSCs morphology; (b) Magnetic nanoparticles (MNP) For PDGFRα; (c) integrin ανβ3 hMSCs, (b,d) histological analysis of hMSCs after 21 days of osteogenic induction; (e) alizarin red s staining; (f) Sirius-red staining. Reproduced with permission from Hu et al. (2013).