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. 2020 Sep;30(9):1228–1242. doi: 10.1101/gr.252106.119

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© 2020 Lopez et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Identification of recurrently altered genes in neuroblastoma by breakpoint analyses. (A–F) Recurrently altered genes ranked based on different breakpoint analyses and mode of impact: (A) gene coding sequences with recurrent SJ-BPs; (B) gene proximal and intronic sequences with recurrent SJ-BPs; (C) gene proximal sequences with recurrent RD-BPs; (D) gene coding sequences with recurrent RD-BPs; (E) gene coding sequences with recurrent CN-BPs; and (F) gene proximal sequences with recurrent CN-BPs. (G) OncoPrint based on the WGS data set recurrently altered genes by SVs detected through orthogonal approaches (SJ-BP and RD-BP) as depicted in bar plot (right). The oncoPrint aggregates three tracks per gene representing different BP analysis: (upper) SJ-BP; (center) RD-BP; and (lower) recurrent pathogenic SNVs.