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. 2020 Oct 8;11:5077. doi: 10.1038/s41467-020-18916-5

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© The Author(s) 2020, corrected publication 2020

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Fig. 3 — a tSNE plot of fibroblasts colored by clusters (up) and subgroup markers (down). b Heatmap of DEGs between different fibroblast subgroups. c IF confirmed the existence of iCAFs and mCAFs (n = 30). Scale bar represents 50 μm. d Enriched GO functions of upregulated genes in iCAFs and mCAFs. e, f GSEA shows top enriched pathways in iCAFs (3E) and mCAFs (3F). NES denotes normalized enrichment score. g Violin plot shows expression level of CXCL12 across major cell types. h Correlation between CXCL12 level and tumor-infiltrated macrophages in TCGA BLCA cohort. Coefficient was calculated with spearman correlation analysis. i High level of CXCL12 predicted poor prognosis in TCGA BLCA cohort. Log-rank p value < 0.05 was considered as statistically significant. j IF recognized CXCL12+ iCAFs in BC tissues. iCAFs are the major derivation of CXCL12 in tumor tissues. Scale bar represents 50 μm.