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. 2020 Oct 8;11(10):834. doi: 10.1038/s41419-020-03051-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b After pretreatment with BDNF and Mn in HT22 cells, representative images of PLA show the interaction between α-Syn and TrkB (red spots), and the nucleus was stained in blue (DAPI). Scale bars = 50 μm. c, d The immunoprecipitation analysis of α-Syn and TrkB is shown. e–g After treating the mice with Mn, the levels of BDNF and TrkB were evaluated by western blotting. n = 6. h–j For HT22 cells transfected with the LV-α-Syn shRNA, the levels of BDNF and TrkB were evaluated by western blotting after Mn treatment. k–m After pretreatment with BDNF and Mn in HT22 cells, the levels of TrkB and α-Syn expression were evaluated by western blotting. n = 4. **P < 0.01, and *P < 0.05 compared to their control counterparts; ^##P < 0.01, and ^#P < 0.05 for comparison between the Mn treatment group.