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. 2020 Sep 25;7:565530. doi: 10.3389/fmolb.2020.565530

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Copyright © 2020 Greenig, Melville, Huntley, Isalan and Mielcarek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scatter plots displaying sex-specific expression paths over time. The top 12 genes with canonical names (ranked by adjusted p-value) identified in the likelihood ratio test for age/sex interaction are displayed. For each gene, transcript count is displayed on the y-axis (with logarithmic scale) and age group on the x-axis. Samples from different sexes are colored differently. Expression of each of these genes is highly associated with an interaction between age and sex. Lines are added to display trajectories between mean expression levels for each sex at each time point. Lines for males (blue) and females (red) are colored differently.