Table 1.
List of genes that exhibit dynamic expression throughout the aging process.
| Gene | LFC (4–15 wk) | LFC (15–8 mo) | LFC (8–22 mo) | Adjusted p-value |
|---|---|---|---|---|
| Fzd6 | 3.79 | −2.17 | 5.68 | 8.27·10−7 |
| Hs6st1 | −8.66 | 1.78 | −8.12 | 1.25·10−6 |
| Slc35e3 | −7.57 | −0.74 | 4.39 | 2.14·10−6 |
| Ap5m1 | 3.61 | −2.51 | −0.96 | 2.52·10−6 |
| Selenok | 6.31 | −0.88 | 10.10 | 2.59·10−6 |
| Mgat4a | 10.33 | −6.27 | −2.66 | 8.77·10−6 |
| Tnni1 | −3.64 | 0.51 | 7.87 | 8.77·10−6 |
| Ube2k | 1.66 | −6.94 | 7.54 | 8.77·10−6 |
| Atmin | −4.15 | 9.19 | −1.08 | 9.09·10−6 |
| Sox6 | 3.97 | −7.95 | −1.45 | 9.09·10−6 |
| Tsnax | −3.39 | −4.71 | 1.10 | 1.13·10−5 |
| Xpo7 | −5.46 | 2.83 | 0.26 | 1.27·10−5 |
| Hscb | −4.59 | 4.00 | 7.07 | 1.78·10−5 |
| Naa10 | −1.78 | 0.25 | 14.34 | 1.78·10−5 |
| Ascc1 | 1.10 | 2.22 | 3.95 | 3.01·10−5 |
| Rpl26-ps5 | 0.71 | 2.60 | 2.02 | 3.49·10−5 |
| Rpl3l | 4.79 | 1.39 | 6.88 | 3.49·10−5 |
| Ddo | −8.19 | 1.39 | 2.56 | 3.87·10−5 |
| Dusp19 | −4.30 | 1.42 | −6.31 | 4.43·10−5 |
| Mturn | 5.23 | 0.62 | −6.41 | 4.43·10−5 |
Each table includes the top 20 genes with the lowest p-values calculated by the likelihood ratio test (LRT) for age, sorted by adjusted p-value. These p-values provide an indication of the age variable's explanatory power in the expression model for each gene. DESeq2's shrunken log2 fold change (LFC) for each pair of consecutive time points is also listed to provide information on each gene's specific expression path.
Fzd6, Frizzled class receptor 6; Hs6st1, Heparan Sulfate 6-O-Sulfotransferase 1; Slc35e3, Solute Carrier Family 35 Member E3; Ap5m1, Adaptor related protein complex 5 subunit mu 1; Selenok, Selenoprotein K; Mgat4a, Alpha-1,3-Manosyl-Glycoprotein 4-beta-N-acetylglucosaminyltransferase A; Tnni1, Troponin I1, slow skeletal type; Ube2k, Ubiquitin-conjugating enzyme E2 K; Atmin, ATM ineractor; Sox6, SRY-box transcription factor 6; Tsnax, Translin-associated factor X; Xpo7, Exportin-7; Hscb, HscB mitochondrial iron-sulfur cluster co-chaperone; Naa10, N-alpha-acetyltransferase 10 NatA catalytic subunit; Ascc1, Activating signal cointegrator 1 complex subunit 1; Rpl26-ps5, Ribosomal protein L26 pseudogene 5; Rpl3l, Ribosomal protein L3-like; Ddo, D-aspartate oxidase; Dusp19, dual-specificity phosphatase 19; Mturn, Maturin, neural progenitor differentiation regulator homolog.